Hotel Twenty One
Via Cola Di Rienzo 23,, Rome, 00192, Italy
Book online now. Rates from EUR57.
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US: 888-205-7322
UK: 0808 145-3778
EU: +1 469-610-3608
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1 Room With 2 Adults Change Search
Check Rates
Rates from EUR 57
Twentyone Hotel is a modern 4-star hotel located on one of Rome’s finest shopping streets. Castel Sant’Angelo as well as the historic centre is only a 10-minute walk away.

Perfectly situated on Via Cola di Rienzo, this boutique hotel of luxury allows guests to explore the stylish Prati district, home of Saint Peter’s Basilica and the Vatican, with ease. Bus and metro links are found close by.

Guests of Twentyone Hotel will enjoy its ultra-modern interiors and minimalist décor. Each of the spacious guestrooms comes with an LCD satellite TV. Guests can also take advantage of free Wi-Fi access in the lounge.

The Friendly staff of Twentyone will be pleased to arrange transfers, trips and guided tours and for guests.

Hotel Services and Facilities

Free WiFi Free parking Free breakfast

Hotel facilities

  • 24 hour front desk
  • Airport Transportation
  • Attraction Shuttle Service
  • Concierge
  • Dry cleaning service
  • Internet Access - Free Public Access
  • Laundry
  • Non-Smoking Facility
  • Parking - Self
  • Restaurant
  • Room Service
  • Wheelchair Access
  • Contactless check-in and check-out are available
For your protection, this hotel is following certain sanitization standards and procedures.
  • Property is cleaned with disinfectant
  • Staff wears personal protective equipment
  • Acrylic shield between guests and staff in main contact areas
  • Guests are provided with free hand sanitizer
  • Social distancing measures are in place
  • Property confirms they are implementing enhanced health & safety measures
  • Individually-wrapped food options are available
  • Individually-wrapped food options are available for breakfast
  • Individually-wrapped food options are available for lunch
  • Individually-wrapped food options are available for dinner
  • Individually-wrapped food options are available through room service
  • Staff temperature checks are conducted regularly
  • Temperature checks are available to guests
  • Bed sheets and towels are washed at a temperature of at least 60°C/140°F
  • Commonly-touched surfaces are cleaned with disinfectant
  • Property confirms they are implementing guest safety measures

Guest reviews

Click here to leave your opinion >>
stayed in July, 2009
Guest Score 7.5 out of 10
The location. The clean and new decoration of the hotel.
No 24h room service; no restaurant or living room. The breakfast was only continental.Some of the employers had difficulty to speak english.


What are the check-in and check-out times at Hotel Twenty One?
The guests can check in from 14:00. Check-out time is 11:00.
What is the nearest airport to Hotel Twenty One?
Rome, Italy (CIA-Ciampino) is located 9.84mi from the property.
Does Hotel Twenty One provide free wi-fi?
We provide complimentary internet access in public areas.
What are the parking options at Hotel Twenty One?
Self Parking is provided on-site.
Is there airport transportation available at Hotel Twenty One?
Guests in need of traveling to/from the airport may arrange transportation with the reception.
Is smoking allowed on the premises?
The establishment is entirely non-smoking.
Is Hotel Twenty One wheelchair accessible?
The hotel has wheelchair accessibility throughout its grounds.
Will room service be provided?
Room service can be arranged for guests staying at the hotel.
Are there restaurants nearby or on-site?
Looking for a place to eat? The property offers at least one full-service restaurant.
Are there laundry services?
Laundry services may be available at an additional cost.
Is there dry cleaning available at Hotel Twenty One?
Dry cleaning services can be found on the premises.
Is there a concierge available at Hotel Twenty One?
A friendly and helpful concierge is always ready to assist with any inquiries.
Are there attraction shuttles provided by the hotel?
Discover the area using the services of an attraction shuttle.
Is the front desk open 24 hours?
Our helpful 24-hour front desk is ready to assist you with any inquiry.

How to book

Making your reservation in Hotel Twenty One is easy and secure. Simply select your dates of stay and click on the “Check Rates” button to submit the form.

After room types and rates are returned to your screen, you will be able to choose the rate you desire by reading the room information in the center of the screen, then clicking on the "Book Now" button on the right side of the screen. After you have selected your desired room type, you will be taken to a "Complete your booking" form. Then you will need to review the "Details of your stay" and fill in the blanks on the "Guest Details" section. Be sure your name and email address are spelled correctly.

After you fill out all of the needed information, press the "Complete reservation" button. To ensure your security, we use a secure commerce server, which encrypts the credit card number and encodes it into a non-usable form.

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Guest reviews
...clean and new decoration of the hotel...
Overall score: 7.5
(out of 10) Based on 1 votes
Click here to leave your opinion

Area information

    • Rome, Italy (CIA-Ciampino) - 9.84 mi
    • Rome, Italy (FCO-Leonardo Da Vinci) - 13.69 mi
    • Museum of the Souls of Purgatory - 0.39 mi
    • Castel Sant'Angelo Museum - 0.47 mi
    • Explora il Museo dei Bambini di Roma - 0.48 mi
    • Altemps Museum - 0.60 mi